| Rank | Game | System | Copies Sold | |
|---|
| 1 |
| Nintendogs | Nintendo DS | 21,670,000 | |
| 2 |
| Wii Play | Nintendo Wii | 20,910,000 | |
| 3 |
| Pokémon Red and Blue | Game Boy | 20,080,000 | |
| 4 |
| Super Mario Bros 3 | Nintendo Entertainment System | 18,000,000 | |
| 5 |
| New Super Mario Bros | Nintendo DS | 17,630,000 | |
| 6 |
| Brain Age: Train Your Brain in Minutes a Day! | Nintendo DS | 16,820,000 | |
| 7 |
| Pokémon Diamond and Pearl | Nintendo DS | 16,480,000 | |
| 8 |
| Gran Turismo 3: A-Spec | Playstation 2 | 14,890,000 | |
| 9 |
| Pokémon Gold and Silver | Game Boy Color | 14,510,000 | |
| 10 |
| Wii Fit | Nintendo Wii | 14,010,000 | |
| 11 |
| Super Mario Land | Game Boy | 14,000,000 | |
| 12 |
| Mario Kart DS | Nintendo DS | 13,790,000 | |
| 13 |
| Mario Kart Wii | Nintendo Wii | 13,670,000 | |
| 14 |
| Brain Age 2: More Training in Minutes a Day! | Nintendo DS | 13,270,000 | |
| 15 |
| Pokémon Ruby and Sapphire | Game Boy Advance | 13,000,000 | |
| 16 |
| Grand Theft Auto: San Andreas | Playstation 2 | 12,000,000 | |
| 17 |
| Pokémon FireRed and LeafGreen | Game Boy Advance | 11,820,000 | |
| 18 |
| Super Mario 64 | Nintendo 64 | 11,000,000 | |
| 19 |
| Gran Turismo | Playstation | 10,850,000 | |
| 20 |
| Animal Crossing: Wild World | Nintendo DS | 10,570,000 | |