| Rank | Game | Copies Sold | |
|---|
| 1 |
| Super Mario Bros. | 40,230,000 | |
| 2 |
| Super Mario Bros. 3 | 18,000,000 | |
| 3 |
| Super Mario Bros. 2 | 10,000,000 | |
| 4 |
| The Legend of Zelda | 6,510,000 | |
| 5 |
| Zelda II: The Adventure of Link | 4,380,000 | |
| 6 |
| Teenage Mutant Ninja Turtles | 4,000,000 | |
| 7 |
| Dragon Warrior III | 3,800,000 | |
| 8 |
| Dragon Warrior IV | 3,100,000 | |
| 9 |
| Golf | 2,460,000 | |
| 10 |
| Dragon Warrior II | 2,400,000 | |
| 11 |
| Baseball | 2,350,000 | |
| 12 |
| Mahjong | 2,130,000 | |
| 13 |
| Family Stadium | 2,050,000 | |
| 14 |
| Tetris | 1,810,000 | |
| 15 |
| Duck Tales | 1,670,000 | |
| 16 |
| Ghosts 'n Goblins | 1,640,000 | |
| 17 |
| Mario Bros. | 1,630,000 | |
| 18 |
| Excitebike | 1,570,000 | |
| 19 |
| Dr. Mario | 1,530,000 | |
| 20 |
| Soccer | 1,530,000 | |
| 21 |
| F-1 Race | 1,520,000 | |
| 22 |
| Mega Man 2 | 1,510,000 | |
| 23 |
| Dragon Warrior | 1,500,000 | |
| 24 |
| Lode Runner | 1,500,000 | |
| 25 |
| Ninja Hattori Kun | 1,500,000 | |
| 26 |
| 4 Players Mahjong | 1,450,000 | |
| 27 |
| Kung-Fu Master | 1,420,000 | |
| 28 |
| Final Fantasy III | 1,400,000 | |
| 29 |
| Family Stadium '87 | 1,300,000 | |
| 30 |
| Xevious | 1,260,000 | |
| 31 |
| Dragon Ball | 1,250,000 | |
| 32 |
| Gegege no Kitaro: Youkai Daimakyou | 1,250,000 | |
| 33 |
| Tennis | 1,210,000 | |
| 34 |
| Chip 'n Dale Rescue Rangers | 1,200,000 | |
| 35 |
| Goemon | 1,200,000 | |
| 36 |
| Twin Bee | 1,200,000 | |
| 37 |
| Doraemon | 1,150,000 | |
| 38 |
| Commando | 1,140,000 | |
| 39 |
| Kid Icarus | 1,090,000 | |
| 40 |
| Mega Man 3 | 1,080,000 | |
| 41 |
| Family Stadium '88 | 1,080,000 | |
| 42 |
| Famicom Jump: Eiyuu Retsuden | 1,060,000 | |
| 43 |
| Adventure Island | 1,050,000 | |
| 44 |
| Kinniku Man: Muscle Tag Match | 1,050,000 | |
| 45 |
| Bomberman | 1,000,000 | |
| 46 |
| Gradius | 1,000,000 | |
| 47 |
| Metal Gear | 1,000,000 | |
| 48 |
| Metroid | 1,000,000 | |