| Rank | Game | Copies Sold | |
|---|
| 1 |
| Grand Theft Auto: San Andreas | 12,000,000 | |
| 2 |
| Gran Turismo 3: A-Spec | 9,530,000 | |
| 3 |
| Grand Theft Auto: Vice City | 9,210,000 | |
| 4 |
| Grand Theft Auto III | 7,509,000 | |
| 5 |
| Metal Gear Solid 2: Sons of Liberty | 7,000,000 | |
| 6 |
| Final Fantasy X | 6,600,000 | |
| 7 |
| Final Fantasy XII | 5,200,000 | |
| 8 |
| Kingdom Hearts | 4,680,000 | |
| 9 |
| Dragon Quest VIII: Journey of the Cursed King | 4,440,000 | |
| 10 |
| Madden NFL 2005 | 4,350,000 | |
| 11 |
| Tekken 5 | 4,300,000 | |
| 12 |
| Jak and Daxter: The Precursor Legacy | 4,200,000 | |
| 13 |
| EyeToy: Play | 4,000,000 | |
| 14 |
| Gran Turismo 4 | 3,960,000 | |
| 15 |
| Madden NFL 2004 | 3,950,000 | |
| 16 |
| Kingdom Hearts II | 3,890,000 | |
| 17 |
| Ratchet & Clank | 3,714,000 | |
| 18 |
| Madden NFL 06 | 3,710,000 | |
| 19 |
| Metal Gear Solid 3: Snake Eater | 3,700,000 | |
| 20 |
| Need for Speed: Underground | 3,600,000 | |
| 21 |
| Medal of Honor: Frontline | 3,400,000 | |
| 22 |
| Guitar Hero II | 3,310,000 | |
| 23 |
| Guitar Hero III: Legends of Rock | 3,233,700 | |
| 24 |
| Ratchet & Clank: Up Your Arsenal | 3,218,000 | |
| 25 |
| Madden NFL 2003 | 3,180,000 | |
| 26 |
| Final Fantasy X-2 | 3,000,000 | |
| 27 |
| The Getaway | 3,000,000 | |
| 28 |
| Ratchet & Clank: Going Commando | 2,966,000 | |
| 29 |
| WWE SmackDown! vs. RAW 2006 | 2,900,000 | |
| 30 |
| Spider-Man: The Movie | 2,810,000 | |
| 31 |
| Madden NFL 07 | 2,800,000 | |
| 32 |
| Crash Bandicoot: The Wrath of Cortex | 2,763,000 | |
| 33 |
| SOCOM: U.S. Navy SEALs | 2,750,000 | |
| 34 |
| Winning Eleven 7 | 2,710,000 | |
| 35 |
| Dragon Ball Z: Budokai | 2,583,000 | |
| 36 |
| The Simpsons Hit & Run | 2,570,000 | |
| 37 |
| Lego Star Wars: The Video Game | 2,480,000 | |
| 38 |
| The Lord of the Rings: The Two Towers | 2,440,000 | |
| 39 |
| God of War | 2,430,000 | |
| 40 |
| Need for Speed: Most Wanted | 2,420,000 | |
| 41 |
| Medal of Honor: Rising Sun | 2,410,000 | |
| 42 |
| Tony Hawk Underground | 2,410,000 | |
| 43 |
| Tony Hawk's Pro Skater 3 | 2,400,000 | |
| 44 |
| Ace Combat 04: Shattered Skies | 2,328,000 | |
| 45 |
| Star Wars: Battlefront II | 2,310,000 | |
| 46 |
| Madden NFL 2002 | 2,300,000 | |
| 47 |
| The Simpsons Road Rage | 2,240,000 | |
| 48 |
| Everybody's Golf 3 | 2,170,000 | |
| 49 |
| Ratchet: Deadlocked | 2,169,000 | |
| 50 |
| Devil May Cry | 2,160,000 | |
| 51 |
| SOCOM II: U.S. Navy SEALs | 2,140,000 | |
| 52 |
| Winning Eleven 8 | 2,110,000 | |
| 53 |
| Max Payne | 2,100,000 | |
| 54 |
| James Bond 007: Agent Under Fire | 2,070,000 | |
| 55 |
| Tekken Tag Tournament | 2,067,000 | |
| 56 |
| True Crime: Streets of LA | 2,060,000 | |
| 57 |
| Resident Evil 4 | 2,050,000 | |
| 58 |
| Onimusha: Warlords | 2,020,000 | |
| 59 |
| Dragon Ball Z: Budokai 2 | 2,007,000 | |
| 60 |
| Need for Speed: Underground 2 | 2,000,000 | |
| 61 |
| ESPN NFL 2K5 | 2,000,000 | |
| 62 |
| God of War II | 2,000,000 | |
| 63 |
| WWE SmackDown! vs. RAW | 2,000,000 | |
| 64 |
| ATV Offroad Fury | 1,990,000 | |
| 65 |
| Onimusha 2: Samurai's Destiny | 1,990,000 | |
| 66 |
| Tekken 4 | 1,979,000 | |
| 67 |
| Star Wars: Battlefront | 1,970,000 | |
| 68 |
| Midnight Club: Street Racing | 1,970,000 | |
| 69 |
| NBA Live 2005 | 1,950,000 | |
| 70 |
| Spider-Man 2 | 1,930,000 | |
| 71 |
| Madden NFL 08 | 1,900,000 | |
| 72 |
| Namco Museum | 1,800,000 | |
| 73 |
| Dragon Ball Z: Budokai 3 | 1,782,000 | |
| 74 |
| ATV Offroad Fury 2 | 1,770,000 | |
| 75 |
| Winning Eleven 6 | 1,750,000 | |
| 76 |
| Sonic Mega Collection Plus | 1,730,000 | |
| 77 |
| Call of Duty: Finest Hour | 1,710,000 | |
| 78 |
| Devil May Cry 2 | 1,700,000 | |
| 79 |
| James Bond 007: Nightfire | 1,700,000 | |
| 80 |
| Mortal Kombat: Deadly Alliance | 1,700,000 | |
| 81 |
| NBA Street | 1,700,000 | |
| 82 |
| Yakuza | 1,700,000 | |
| 83 |
| Winning Eleven 10 | 1,690,000 | |
| 84 |
| WWE SmackDown! Shut Your Mouth | 1,680,000 | |
| 85 |
| Sonic Heroes | 1,680,000 | |
| 86 |
| Dragon Quest V | 1,640,000 | |
| 87 |
| Winning Eleven 9 | 1,640,000 | |
| 88 |
| Grand Theft Auto: Liberty City Stories | 1,620,000 | |
| 89 |
| Need for Speed: Hot Pursuit 2 | 1,610,000 | |
| 90 |
| Star Wars Episode III: Revenge of the Sith | 1,610,000 | |
| 91 |
| Jak II | 1,600,000 | |
| 92 |
| NBA Street Vol. 2 | 1,600,000 | |
| 93 |
| Dynasty Warriors 4 | 1,589,000 | |
| 94 |
| Gran Turismo Concept | 1,560,000 | |
| 95 |
| WWE SmackDown! Here Comes the Pain | 1,540,000 | |
| 96 |
| Enter the Matrix | 1,540,000 | |
| 97 |
| Guitar Hero | 1,530,000 | |
| 98 |
| WWE SmackDown vs. Raw 2007 | 1,530,000 | |
| 99 |
| Onimusha 3: Demon Siege | 1,520,000 | |
| 100 |
| Bully | 1,500,000 | |