| Rank | Game | Copies Sold | |
|---|
| 1 |
| Wii Sports | 40,500,000 | |
| 2 |
| Wii Play | 20,910,000 | |
| 3 |
| Wii Fit | 14,010,000 | |
| 4 |
| Mario Kart Wii | 13,670,000 | |
| 5 |
| Super Smash Bros. Brawl | 8,100,000 | |
| 6 |
| Super Mario Galaxy | 7,660,000 | |
| 7 |
| Mario Party 8 | 6,280,000 | |
| 8 |
| The Legend of Zelda: Twilight Princess | 4,520,000 | |
| 9 |
| Link's Crossbow Training | 3,440,000 | |
| 10 |
| Mario & Sonic at the Olympic Games | 3,400,000 | |