| Rank | College | Enrollment | State | |
| 1 |
| University of Phoenix, Online Campus | 117,309 | Arizona | |
| 2 |
| Miami-Dade College | 54,169 | Florida | |
| 3 |
| Arizona State University | 51,612 | Arizona | |
| 4 |
| University of Minnesota | 51,175 | Minnesota | |
| 5 |
| Western International University | 50,663 | Arizona | |
| 6 |
| Ohio State University | 50,504 | Ohio | |
| 7 |
| University of Texas at Austin | 49,696 | Texas | |
| 8 |
| University of Florida | 49,693 | Florida | |
| 9 |
| Michigan State University | 45,166 | Michigan | |
| 10 |
| Texas A & M University | 44,910 | Texas | |
| 11 |
| University of Central Florida | 44,856 | Florida | |
| 12 |
| City College of San Francisco | 43,255 | California | |
| 13 |
| University of South Florida | 42,660 | Florida | |
| 14 |
| University of Illinois at Urbana-Champaign | 41,938 | Illinois | |
| 15 |
| University of Wisconsin | 40,793 | Wisconsin | |
| 16 |
| Pennsylvania State University | 40,709 | Pennsylvania | |
| 17 |
| Purdue University | 40,151 | Indiana | |
| 18 |
| New York University | 40,004 | New York | |
| 19 |
| University of Michigan | 39,993 | Michigan | |
| 20 |
| North Harris Montgomery Community College | 39,949 | Texas | |
| 21 |
| Houston Community College System | 39,516 | Texas | |
| 22 |
| University of Washington | 39,251 | Washington | |
| 23 |
| Florida State University | 39,146 | Florida | |
| 24 |
| Indiana University | 37,958 | Indiana | |
| 25 |
| Northern Virginia Community College | 37,740 | Virginia | |
| 26 |
| University of Arizona | 37,036 | Arizona | |
| 27 |
| Florida International University | 36,904 | Florida | |
| 28 |
| University of California, Los Angeles | 35,625 | California | |
| 29 |
| University of Maryland, College Park | 35,369 | Maryland | |
| 30 |
| University of Houston | 35,344 | Texas | |
| 31 |
| California State University, Fullerton | 35,040 | California | |
| 32 |
| Tarrant County College District | 34,892 | Texas | |
| 33 |
| Community College of Southern Nevada | 34,551 | Nevada | |
| 34 |
| California State University, Long Beach | 34,547 | California | |
| 35 |
| Rutgers University | 34,449 | New Jersey | |
| 36 |
| Louisiana State University | 34,128 | Louisiana | |
| 37 |
| Brigham Young University | 34,067 | Utah | |
| 38 |
| Temple University | 33,695 | Pennsylvania | |
| 39 |
| University of Georgia | 33,660 | Georgia | |
| 40 |
| University of California, Berkeley | 33,547 | California | |
| 41 |
| California State University | 33,243 | California | |
| 42 |
| American InterContinental University | 32,880 | Illinois | |
| 43 |
| University of Southern California | 32,836 | California | |
| 44 |
| Wayne State University | 32,160 | Michigan | |
| 45 |
| Santa Ana College | 32,096 | California | |
| 46 |
| University of North Texas | 31,958 | Texas | |
| 47 |
| Austin Community College | 31,908 | Texas | |
| 48 |
| Broward Community College | 31,835 | Florida | |
| 49 |
| San Diego State University | 31,802 | California | |
| 50 |
| University of Colorado at Boulder | 31,589 | Colorado | |
| 51 |
| Boston University | 30,957 | Massachusetts | |
| 52 |
| Pima Community College | 30,884 | Arizona | |
| 53 |
| University of Utah | 30,558 | Utah | |
| 54 |
| American River College | 30,527 | California | |
| 55 |
| North Carolina State University | 30,148 | North Carolina | |
| 56 |
| San Jose State University | 29,975 | California | |
| 57 |
| Indiana University-Purdue | 29,933 | Indiana | |
| 58 |
| George Mason University | 29,728 | Virginia | |
| 59 |
| Valencia Community College | 29,544 | Florida | |
| 60 |
| Virginia Commonwealth University | 29,168 | Virginia | |
| 61 |
| Riverside Community College | 29,160 | California | |
| 62 |
| San Francisco State University | 28,950 | California | |
| 63 |
| Santa Monica College | 28,908 | California | |
| 64 |
| University of California, Davis | 28,815 | California | |
| 65 |
| University of Tennessee | 28,512 | Tennessee | |
| 66 |
| University of Iowa | 28,426 | Iowa | |
| 67 |
| University of Nevada, Las Vegas | 28,134 | Nevada | |
| 68 |
| Texas Tech University | 28,001 | Texas | |
| 69 |
| Virginia Polytechnic Institute and State University | 27,979 | Virginia | |
| 70 |
| California State University, Sacramento | 27,932 | California | |
| 71 |
| University of Cincinnati | 27,932 | Ohio | |
| 72 |
| University of Missouri | 27,930 | Missouri | |
| 73 |
| Colorado State University | 27,780 | Colorado | |
| 74 |
| University of Wisconsin, Milwaukee | 27,502 | Wisconsin | |
| 75 |
| University of Maryland, University College | 27,429 | Maryland | |
| 76 |
| University of Texas at San Antonio | 27,337 | Texas | |
| 77 |
| Strayer University | 27,309 | District of Columbia | |
| 78 |
| University of North Carolina at Chapel Hill | 27,276 | North Carolina | |
| 79 |
| Central Michigan University | 27,221 | Michigan | |
| 80 |
| SUNY at Buffalo | 27,220 | New York | |
| 81 |
| Pasadena City College | 27,199 | California | |
| 82 |
| Mount San Antonio College | 27,195 | California | |
| 83 |
| Texas State University, San Marcos | 27,129 | Texas | |
| 84 |
| College of DuPage | 27,117 | Illinois | |
| 85 |
| University of South Carolina at Columbia | 27,065 | South Carolina | |
| 86 |
| University of Kansas | 26,934 | Kansas | |
| 87 |
| Troy State University | 26,880 | Alabama | |
| 88 |
| El Paso Community College | 26,667 | Texas | |
| 89 |
| University of Pittsburgh | 26,559 | Pennsylvania | |
| 90 |
| Mesa Community College | 26,528 | Arizona | |
| 91 |
| University of Oklahoma | 26,506 | Oklahoma | |
| 92 |
| Nova Southeastern University | 26,335 | Florida | |
| 93 |
| Western Michigan University | 26,239 | Michigan | |
| 94 |
| University of New Mexico | 26,172 | New Mexico | |
| 95 |
| West Virginia University | 26,051 | West Virginia | |
| 96 |
| National University | 26,035 | California | |
| 97 |
| Georgia State University | 25,967 | Georgia | |
| 98 |
| Iowa State University | 25,741 | Iowa | |
| 99 |
| University of Kentucky | 25,672 | Kentucky | |
| 100 |
| Florida Atlantic University | 25,645 | Florida | |