| Rank | Company | 2008 Revenue | 2008 Profit | |
| 1 |
| Wal-Mart | $378,799,000,000 | $12,731,000,000 | |
| 2 |
| Exxon Mobil | $372,824,000,000 | $40,610,000,000 | |
| 3 |
| Chevron | $210,783,000,000 | $18,688,000,000 | |
| 4 |
| General Motors | $182,347,000,000 | -$38,732,000,000 | |
| 5 |
| ConocoPhillips | $178,558,000,000 | $11,891,000,000 | |
| 6 |
| General Electric | $176,656,000,000 | $22,208,000,000 | |
| 7 |
| Ford Motor Company | $172,468,000,000 | -$2,723,000,000 | |
| 8 |
| Citigroup | $159,229,000,000 | $3,617,000,000 | |
| 9 |
| Bank of America | $119,190,000,000 | $14,982,000,000 | |
| 10 |
| AT&T | $118,928,000,000 | $11,951,000,000 | |
| 11 |
| Berkshire Hathaway | $118,245,000,000 | $13,213,000,000 | |
| 12 |
| J.P. Morgan Chase & Co. | $116,353,000,000 | $15,365,000,000 | |
| 13 |
| American International Group | $110,064,000,000 | $6,200,000,000 | |
| 14 |
| Hewlett-Packard | $104,286,000,000 | $7,264,000,000 | |
| 15 |
| IBM | $98,786,000,000 | $10,418,000,000 | |
| 16 |
| Valero | $96,758,000,000 | $5,234,000,000 | |
| 17 |
| Verizon Communications | $93,775,000,000 | $5,521,000,000 | |
| 18 |
| McKesson | $93,574,000,000 | $913,000,000 | |
| 19 |
| Cardinal Health | $88,363,900,000 | $1,931,100,000 | |
| 20 |
| Goldman Sachs Group | $87,968,000,000 | $11,599,000,000 | |
| 21 |
| Morgan Stanley | $87,879,000,000 | $3,209,000,000 | |
| 22 |
| Home Depot | $84,740,000,000 | $4,395,000,000 | |
| 23 |
| Procter & Gamble | $76,476,000,000 | $10,340,000,000 | |
| 24 |
| CVS Caremark Corporation | $76,329,500,000 | $2,637,000,000 | |
| 25 |
| UnitedHealth Group | $75,431,000,000 | $4,654,000,000 | |
| 26 |
| Kroger | $70,234,700,000 | $1,180,500,000 | |
| 27 |
| Boeing | $66,387,000,000 | $4,074,000,000 | |
| 28 |
| AmerisourceBergen | $66,074,300,000 | $469,200,000 | |
| 29 |
| Costco | $64,400,200,000 | $1,082,800,000 | |
| 30 |
| Merrill Lynch | $64,217,000,000 | -$7,777,000,000 | |
| 31 |
| Target | $63,367,000,000 | $2,849,000,000 | |
| 32 |
| State Farm Insurance | $61,611,600,000 | $5,463,700,000 | |
| 33 |
| WellPoint | $61,134,300,000 | $3,345,400,000 | |
| 34 |
| Dell | $61,133,000,000 | $2,947,000,000 | |
| 35 |
| Johnson & Johnson | $61,095,000,000 | $10,576,000,000 | |
| 36 |
| Marathon Oil | $60,044,000,000 | $3,956,000,000 | |
| 37 |
| Lehman Brothers Bank FSB | $59,003,000,000 | $4,192,000,000 | |
| 38 |
| Wachovia | $55,528,000,000 | $6,312,000,000 | |
| 39 |
| United Technologies Corporation | $54,759,000,000 | $4,224,000,000 | |
| 40 |
| Walgreens | $53,762,000,000 | $2,041,300,000 | |
| 41 |
| Wells Fargo | $53,593,000,000 | $8,057,000,000 | |
| 42 |
| Dow Chemical Company | $53,513,000,000 | $2,887,000,000 | |
| 43 |
| MetLife | $53,150,000,000 | $4,317,000,000 | |
| 44 |
| Microsoft | $51,122,000,000 | $14,065,000,000 | |
| 45 |
| Sears Holdings Corporation | $50,703,000,000 | $826,000,000 | |
| 46 |
| United Parcel Service | $49,692,000,000 | $382,000,000 | |
| 47 |
| Pfizer | $48,418,000,000 | $8,144,000,000 | |
| 48 |
| Lowe's | $48,283,000,000 | $2,809,000,000 | |
| 49 |
| Time Warner | $46,615,000,000 | $4,387,000,000 | |
| 50 |
| Caterpillar Inc. | $44,958,000,000 | $3,541,000,000 | |
| 51 |
| Medco Health Solutions | $44,506,200,000 | $912,000,000 | |
| 52 |
| Archer Daniels Midland | $44,018,000,000 | $2,162,000,000 | |
| 53 |
| Fannie Mae | $43,355,000,000 | -$2,050,000,000 | |
| 54 |
| Freddie Mac | $43,104,000,000 | -$3,094,000,000 | |
| 55 |
| Safeway | $42,286,000,000 | $888,400,000 | |
| 56 |
| Sunoco | $42,101,000,000 | $891,000,000 | |
| 57 |
| Lockheed Martin | $41,862,000,000 | $3,033,000,000 | |
| 58 |
| Sprint Nextel | $40,146,000,000 | -$29,580,000,000 | |
| 59 |
| PepsiCo | $39,474,000,000 | $5,658,000,000 | |
| 60 |
| Intel Corporation | $38,334,000,000 | $6,976,000,000 | |
| 61 |
| Altria Group | $38,051,000,000 | $9,786,000,000 | |
| 62 |
| SuperValu | $37,406,000,000 | $452,000,000 | |
| 63 |
| Kraft Foods | $37,241,000,000 | $2,590,000,000 | |
| 64 |
| Allstate | $36,769,000,000 | $4,636,000,000 | |
| 65 |
| Motorola | $36,622,000,000 | -$49,000,000 | |
| 66 |
| Best Buy | $35,934,000,000 | $1,377,000,000 | |
| 67 |
| The Walt Disney Company | $35,882,000,000 | $4,687,000,000 | |
| 68 |
| FedEx | $35,214,000,000 | $2,016,000,000 | |
| 69 |
| Ingram Micro | $35,047,100,000 | $275,900,000 | |
| 70 |
| Sysco | $35,042,100,000 | $1,001,100,000 | |
| 71 |
| Cisco Systems | $34,922,000,000 | $7,333,000,000 | |
| 72 |
| Johnson Controls | $34,678,000,000 | $1,252,000,000 | |
| 73 |
| Honeywell | $34,589,000,000 | $2,444,000,000 | |
| 74 |
| Prudential Financial | $34,401,000,000 | $3,704,000,000 | |
| 75 |
| American Express | $32,316,000,000 | $4,012,000,000 | |
| 76 |
| Northrop Grumman | $32,032,000,000 | $1,790,000,000 | |
| 77 |
| Hess Corporation | $31,924,000,000 | $1,832,000,000 | |
| 78 |
| GMAC Real Estate | $31,490,000,000 | -$2,332,000,000 | |
| 79 |
| Comcast | $30,895,000,000 | $2,587,000,000 | |
| 80 |
| Alcoa | $30,748,000,000 | $2,564,000,000 | |
| 81 |
| DuPont | $30,653,000,000 | $2,988,000,000 | |
| 82 |
| New York Life Insurance Company | $29,279,600,000 | $1,141,800,000 | |
| 83 |
| Coca-Cola | $28,857,000,000 | $5,981,000,000 | |
| 84 |
| News Corporation | $28,655,000,000 | $3,426,000,000 | |
| 85 |
| Aetna | $27,599,600,000 | $1,831,000,000 | |
| 86 |
| TIAA-CREF | $27,526,000,000 | $1,438,800,000 | |
| 87 |
| General Dynamics | $27,294,000,000 | $2,072,000,000 | |
| 88 |
| Tyson Foods | $26,900,000,000 | $268,000,000 | |
| 89 |
| Hospital Corporation of America | $26,858,000,000 | $874,000,000 | |
| 90 |
| Enterprise GP Holdings | $26,713,800,000 | $109,000,000 | |
| 91 |
| Macy's | $26,340,000,000 | $893,000,000 | |
| 92 |
| Delphi | $26,160,000,000 | -$3,065,000,000 | |
| 93 |
| Travelers Co. | $26,017,000,000 | $4,601,000,000 | |
| 94 |
| Liberty Mutual | $25,961,000,000 | $1,518,000,000 | |
| 95 |
| The Hartford | $25,916,000,000 | $2,949,000,000 | |
| 96 |
| Abbott Laboratories | $25,914,200,000 | $3,606,300,000 | |
| 97 |
| Washington Mutual | $25,531,000,000 | -$67,000,000 | |
| 98 |
| Humana | $25,290,000,000 | $833,700,000 | |
| 99 |
| Massachusetts Mutual Life Insurance Company | $25,268,200,000 | $722,000,000 | |
| 100 |
| 3M | $24,462,000,000 | $4,096,000,000 | |