It's no surprise that an oil company leads the list of 2007's top profit-makers. Exxon Mobil, the world's biggest oil company, posted a 2007 profit that was almost twice as much as that of the next company on this list, General Electric. It is the highest-ever annual profit from a U.S. company, a record Exxon also set in 2006 and 2005. Earnings rose 2.8% from 2006 on a sales increase of 7.4%.