| 2006 | Academy Award for Actress in a Supporting Role, Abigail Breslin |
| 2006 | Academy Award for Best Picture, Marc Turtletaub |
| 2006 | Academy Award for Best Original Screenplay, Michael Arndt |
| 2006 | Academy Award for Actor in a Supporting Role, Alan Arkin |
| 2006 | BAFTA Award for Best Actress in a Supporting Role, Abigail Breslin |
| 2006 | BAFTA Award for Best Actress in a Supporting Role, Toni Collette |
| 2006 | BAFTA Award for Best Actor in a Supporting Role, Alan Arkin |
| 2006 | BAFTA Award for Best Direction, Valerie Faris |
| 2006 | BAFTA Award for Best Film, David T. Friendly |
| 2007 | Golden Globe Award for Best Actress - Musical or Comedy Film, Toni Collette |
| 2007 | Golden Globe Award for Best Film - Musical or Comedy, David T. Friendly |
| 2006 | Broadcast Film Critics Association Award for Best Film |
| 2006 | Broadcast Film Critics Association Award for Best Cast |
| 2006 | Satellite Award for Best Film – Musical or Comedy, Fox Searchlight Pictures |
| 2006 | DGA Award for Outstanding Directorial Achievement in Feature Film, Jonathan Dayton |
| 2006 | Satellite Award for Best Supporting Actress – Motion Picture, Abigail Breslin |
| 2007 | Costume Designers Guild Award for Best Costume Design - Contemporary Film, Nancy Steiner |
| 2006 | Satellite Award for Best Supporting Actor – Motion Picture, Alan Arkin |
| 2007 | Independent Spirit Award for Best Director, Valerie Faris |
| 2007 | Independent Spirit Award for Best Supporting Male, Alan Arkin |
| 2007 | Independent Spirit Award for Best Supporting Male, Paul Dano |
| 2006 | Broadcast Film Critics Association Award for Best Supporting Actor, Alan Arkin |
| 2006 | BFCA Critics' Choice Award for Best Comedy, Jonathan Dayton |
| 2006 | BFCA Critics' Choice Award for Best Young Actor, Paul Dano |
| 2006 | BFCA Critics' Choice Award for Best Young Actress, Abigail Breslin |
| 2007 | MTV Movie Award for Best Breakthrough Performance, Abigail Breslin |
| 2007 | MTV Movie Award for Best Movie |
| 2007 | Independent Spirit Award for Best Feature, Ron Yerxa |
| 2007 | Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Supporting Role, Abigail Breslin |
| 2007 | Screen Actors Guild Award for Best Supporting Actor - Motion Picture, Alan Arkin |
| 2007 | Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture, Alan Arkin |
| 2006 | Satellite Award for Best Performance by an Actress in a Motion Picture, Comedy or Musical, Toni Collette |
| 2006 | BAFTA Award for Best Original Screenplay, Michael Arndt |
| 2007 | César Award for Best Foreign Film, Jonathan Dayton |
| 2007 | David di Donatello for Best Foreign Film, Jonathan Dayton |
| 2006 | Gotham Independent Film Award for Best Ensemble Performance, Abigail Breslin |
| 2006 | Gotham Independent Film Award for Breakthrough Actor, Abigail Breslin |
| 2007 | Producers Guild of America Award for Best Theatrical Motion Picture, Marc Turtletaub |
| 2007 | Australian Film Institute International Award for Best Actress, Toni Collette |
| 2006 | National Society of Film Critics Award for Best Supporting Actor, Alan Arkin |
| 2006 | Broadcast Film Critics Association Award for Best Screenplay, Michael Arndt |
| 2007 | Writers Guild of America Award for Best Original Screenplay, Michael Arndt |
| 2007 | Independent Spirit Award for Best First Screenplay, Michael Arndt |