| Rank | Series | Viewers | Date of Finale | Network | |
|---|
| 1 |
| M*A*S*H | 105,900,000 | 1/28/1983 | CBS | |
| 2 |
| Cheers | 80,400,000 | 5/20/1993 | NBC | |
| 3 |
| Seinfeld | 76,300,000 | 5/14/1998 | NBC | |
| 4 |
| Friends | 52,500,000 | 5/6/2004 | NBC | |
| 5 |
| Magnum, P.I. | 50,700,000 | 5/1/1988 | CBS | |
| 6 |
| The Tonight Show | 50,000,000 | 5/22/1992 | NBC | |
| 7 |
| The Cosby Show | 44,400,000 | 4/30/1992 | NBC | |
| 8 |
| All in the Family | 40,200,000 | 4/8/1979 | CBS | |
| 9 |
| Family Ties | 36,300,000 | 5/14/1989 | NBC | |
| 10 |
| Home Improvement | 35,500,000 | 5/25/1999 | ABC | |
| 11 |
| Dallas | 33,300,000 | 5/3/1991 | CBS | |
| 12 |
| Everybody Loves Raymond | 32,900,000 | 5/16/2005 | CBS | |
| 13 |
| Gunsmoke | 30,900,000 | 3/31/1975 | CBS | |
| 14 |
| The Fugitive | 30,000,000 | 8/29/1967 | ABC | |
| 15 |
| Newhart | 29,500,000 | 5/21/1990 | CBS | |
| 16 |
| The Golden Girls | 27,200,000 | 5/7/1992 | NBC | |
| 17 |
| Frasier | 25,200,000 | 5/13/2004 | NBC | |
| 18 |
| Night Court | 24,600,000 | 5/13/1992 | NBC | |
| 19 |
| Full House | 24,300,000 | 5/23/1995 | ABC | |
| 20 |
| St. Elsewhere | 22,500,000 | 5/25/1988 | NBC | |
| 21 |
| MacGyver | 22,300,000 | 5/21/1992 | ABC | |
| 22 |
| L.A. Law | 22,100,000 | 5/19/1994 | NBC | |
| 23 |
| ALF | 21,700,000 | 3/24/1990 | NBC | |
| 24 |
| Growing Pains | 21,100,000 | 4/25/1992 | ABC | |
| 25 |
| The Wonder Years | 21,000,000 | 5/12/1993 | ABC | |
| 26 |
| Quantum Leap | 20,600,000 | 5/5/1993 | NBC | |
| 27 |
| Who's the Boss? | 20,500,000 | 4/25/1992 | ABC | |
| 28 |
| The Fresh Prince of Bel-Air | 19,900,000 | 5/20/1996 | NBC | |
| 29 |
| Mad About You | 19,800,000 | 5/24/1999 | NBC | |
| 30 |
| Knots Landing | 19,600,000 | 5/13/1993 | CBS | |
| 31 |
| Bonanza | 19,300,000 | 1/16/1973 | NBC | |
| 32 |
| Will & Grace | 18,400,000 | 5/18/2006 | NBC | |
| 33 |
| The Facts of Life | 18,200,000 | 5/7/1988 | NBC | |
| 34 |
| Jake and the Fatman | 18,100,000 | 5/6/1992 | CBS | |
| 35 |
| Major Dad | 17,900,000 | 4/16/1993 | CBS | |
| 36 |
| Murphy Brown | 17,500,000 | 5/18/1998 | CBS | |
| 37 |
| Roseanne | 16,600,000 | 5/20/1997 | ABC | |
| 38 |
| NYPD Blue | 16,100,000 | 5/1/2005 | ABC | |
| 39 |
| Miami Vice | 16,100,000 | 6/28/1989 | NBC | |
| 40 |
| Married... with Children | 15,200,000 | 5/5/1997 | FOX | |
| 41 |
| Kate & Allie | 14,900,000 | 5/22/1989 | CBS | |
| 42 |
| Dynasty | 14,700,000 | 5/11/1989 | ABC | |
| 43 |
| Monday Night Football | 14,400,000 | 12/26/2005 | ABC | |
| 44 |
| Beverly Hills, 90210 | 14,400,000 | 5/17/2000 | FOX | |
| 45 |
| JAG | 14,000,000 | 4/29/2005 | CBS | |
| 46 |
| The King of Queens | 13,500,000 | 5/14/2007 | CBS | |
| 47 |
| Providence | 13,300,000 | 12/20/2002 | NBC | |
| 48 |
| Life Goes On | 13,200,000 | 5/23/1993 | ABC | |
| 49 |
| The X-Files | 13,200,000 | 5/19/2002 | FOX | |
| 50 |
| Touched by an Angel | 12,900,000 | 4/27/2003 | CBS | |
| 51 |
| Falcon Crest | 12,300,000 | 5/17/1990 | CBS | |
| 52 |
| 3rd Rock from the Sun | 11,900,000 | 5/22/2001 | NBC | |
| 53 |
| The Sopranos | 11,900,000 | 6/10/2007 | HBO | |
| 54 |
| Ally McBeal | 11,500,000 | 5/20/2002 | FOX | |
| 55 |
| The Nanny | 11,100,000 | 5/12/1999 | CBS | |
| 56 |
| The Practice | 10,900,000 | 5/16/2004 | ABC | |
| 57 |
| Walker, Texas Ranger | 10,800,000 | 5/19/2001 | CBS | |
| 58 |
| Judging Amy | 10,800,000 | 5/3/2005 | CBS | |
| 59 |
| Sex and the City | 10,600,000 | 2/22/2004 | HBO | |
| 60 |
| Melrose Place | 10,400,000 | 5/24/1999 | FOX | |
| 61 |
| Dr. Quinn, Medicine Woman | 10,200,000 | 5/16/1998 | CBS | |
| 62 |
| The West Wing | 10,100,000 | 5/14/2006 | NBC | |
| 63 |
| That '70s Show | 9,800,000 | 5/18/2006 | FOX | |
| 64 |
| A Different World | 9,300,000 | 5/8/1993 | NBC | |
| 64 |
| Cosby | 7,500,000 | 4/28/2000 | CBS | |