The Mystical Nativity is a painting of circa 1500–1501 by the Italian Renaissance master Sandro Botticelli, in the National Gallery in London. Botticelli built up the image using oil paint on canvas. It is his only signed work, and has a very unusual iconography for a Nativity. The Greek inscription at the top translates as: "This picture, at the end of the year 1500, in the troubles of Italy, I Alessandro, in the half-time after the time, painted, according to the eleventh [chapter] of Saint John, in the second woe of the Apocalypse, during the release of the devil for three-and-a-half... years; then he shall be bound in the twelfth [chapter] and we shall see [him buried] as in this picture". Botticelli believed himself to be living during the Tribulation, possibly due to the upheavals in Europe at the time, and was predicting Christ's Millennium as stated in Biblical text. It has been suggested that the painting may be connected with the influence of Savonarola, whose influence appears in a number of late paintings by Botticelli, though the contents of the image may have been specified by the person commissioning it.
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