| Rank | High School | State | College Readiness | |
| 1 | Thomas Jefferson High School for Science and Technology Alexandria | Virginia | 100.0 | |
| 2 | Oxford Academy Cypress | California | 99.5 | |
| 3 | Pacific Collegiate Charter Santa Cruz | California | 98.8 | |
| 4 | High Technology High School Lincroft | New Jersey | 98.4 | |
| 5 | Design and Architectural Senior High Miami | Florida | 97.8 | |
| 5 | International Academy Bloomfield Hills | Michigan | 97.8 | |
| 7 | International Baccalaureate School at BHS Bartow | Florida | 97.5 | |
| 8 | Preuss School UCSD La Jolla | California | 97.1 | |
| 9 | Academic Magnet High School No. Charleston | South Carolina | 95.5 | |
| 10 | Gretchen Whitney High Cerritos | California | 94.4 | |
| 10 | Maine School of Science & Math Limestone | Maine | 94.4 | |
| 10 | Pine View School Osprey | Florida | 94.4 | |
| 13 | Basis Tucson Tucson | Arizona | 93.8 | |
| 14 | International School Bellevue | Washington | 91.8 | |
| 15 | Ridgeview Classical Charter Schools Fort Collins | Colorado | 91.3 | |
| 16 | Benjamin Franklin Senior High School New Orleans | Louisiana | 90.7 | |
| 17 | Early College at Guilford Greensboro | North Carolina | 90.0 | |
| 18 | Idea College Preparatory Donna | Texas | 88.9 | |
| 18 | Raleigh Charter High Raleigh | North Carolina | 88.9 | |
| 18 | School of Science & Engineering Dallas | Texas | 88.9 | |
| 21 | Lennox Mathematics-Science and Technology Academy Lennox | California | 88.6 | |
| 22 | University High School Tucson | Arizona | 87.7 | |
| 23 | Stuyvesant High School New York | New York | 87.6 | |
| 24 | International Community School Kirkland | Washington | 87.5 | |
| 25 | Loveless Academic Magnet Program High School Montgomery | Alabama | 86.8 | |
| 26 | California Academy of Mathematics and Science Carson | California | 85.8 | |
| 27 | Boston Latin Boston | Massachusetts | 84.3 | |
| 27 | High School of American Studies at Lehman College Bronx | New York | 84.3 | |
| 27 | School for the Talented and Gifted Dallas | Texas | 84.3 | |
| 30 | Hume Fogg Magnet High School Nashville | Tennessee | 82.8 | |
| 31 | Dual Language and Asian Studies High School New York | New York | 82.4 | |
| 31 | Staten Island Technical High School Staten Island | New York | 82.4 | |
| 33 | Bronx High School of Science School Bronx | New York | 82.0 | |
| 34 | Northside College Preparatory High School Chicago | Illinois | 81.9 | |
| 35 | City Honors School at Fosdick Masten Park Buffalo | New York | 81.8 | |
| 36 | Walnut Hills High School Cincinnati | Ohio | 81.6 | |
| 37 | Yonkers High School Yonkers | New York | 80.7 | |
| 38 | Baccalaureate School of Global Education Long Island City | New York | 79.8 | |
| 38 | Lowell High San Francisco | California | 79.8 | |
| 40 | The Science Academy Mercedes | Texas | 79.7 | |
| 41 | Martin Luther King Jr. Magnet - Pearl High School Nashville | Tennessee | 78.6 | |
| 42 | Charter School of Wilmington Wilmington | Delaware | 78.1 | |
| 43 | Stanton College Preparatory Jacksonville | Florida | 77.8 | |
| 44 | Walt Whitman High Bethesda | Maryland | 76.9 | |
| 45 | University High Fresno | California | 76.5 | |
| 46 | Horace Greeley High School Chappaqua | New York | 75.3 | |
| 47 | Dr. Ronald McNair Academy High School Jersey City | New Jersey | 74.8 | |
| 48 | Great Neck South High School Great Neck | New York | 74.2 | |
| 48 | Queens High School of Science at York College Jamaica | New York | 74.2 | |
| 50 | Wyoming High School Wyoming | Ohio | 74.1 | |
| 51 | Edgemont Junior-Senior High School Scarsdale | New York | 73.9 | |
| 52 | Oscar De La Hoya Animo Charter High Los Angeles | California | 73.2 | |
| 52 | Yes College Preparatory School Houston | Texas | 73.2 | |
| 54 | Thomas S. Wootton High Rockville | Maryland | 73.0 | |
| 55 | McLean High McLean | Virginia | 72.5 | |
| 56 | Michael E. DeBakey High School for Health Professions Houston | Texas | 72.2 | |
| 57 | Winston Churchill High Potomac | Maryland | 72.0 | |
| 58 | Westshore Junior/Senior High School Melbourne | Florida | 71.8 | |
| 59 | Northland Preparatory Academy Flagstaff | Arizona | 71.6 | |
| 60 | Alexander W. Dreyfoos Jr. School of the Arts West Palm Beach | Florida | 71.5 | |
| 60 | Mission San Jose High Fremont | California | 71.5 | |
| 62 | Jericho Senior High School Jericho | New York | 70.9 | |
| 63 | Payton College Preparatory High School Chicago | Illinois | 70.8 | |
| 64 | Piedmont High Piedmont | California | 70.1 | |
| 65 | South Texas Academy of Medical Tech San Benito | Texas | 70.0 | |
| 66 | Masterman Julia R Secondary School Philadelphia | Pennsylvania | 69.9 | |
| 67 | Brooklyn Technical High School Brooklyn | New York | 69.8 | |
| 68 | Signature School Inc. Evansville | Indiana | 69.5 | |
| 69 | Peak To Peak Charter School Lafayette | Colorado | 69.4 | |
| 70 | Hawthorne Math and Science Academy High Hawthorne | California | 69.3 | |
| 71 | Townsend Harris High School Flushing | New York | 69.0 | |
| 72 | Paxon School/Advanced Studies Jacksonville | Florida | 68.9 | |
| 73 | Monta Vista High Cupertino | California | 68.8 | |
| 74 | Henry M. Gunn High Palo Alto | California | 68.2 | |
| 75 | Pittsford Sutherland High School Pittsford | New York | 68.0 | |
| 76 | East Chapel Hill High Chapel Hill | North Carolina | 66.9 | |
| 76 | Langley High McLean | Virginia | 66.9 | |
| 78 | Bellevue High School Bellevue | Washington | 66.8 | |
| 79 | Carnegie Vanguard High School Houston | Texas | 66.3 | |
| 79 | Saratoga High Saratoga | California | 66.3 | |
| 81 | Highland Park High School Dallas | Texas | 65.7 | |
| 82 | High School for Health Professions Mercedes | Texas | 65.5 | |
| 82 | Suncoast Community High School Riviera Beach | Florida | 65.5 | |
| 84 | Cold Spring Harbor High School Cold Spring Harbor | New York | 64.9 | |
| 85 | Newport Senior High School Bellevue | Washington | 64.6 | |
| 86 | Maritime & Science Technology Academy Miami | Florida | 64.4 | |
| 87 | Blind Brook High School Rye Brook | New York | 64.2 | |
| 88 | Wheatley School Old Westbury | New York | 63.6 | |
| 89 | Davidson Magnet School Augusta | Georgia | 63.4 | |
| 90 | Woodson High Fairfax | Virginia | 63.2 | |
| 91 | d'Evelyn Junior/Senior High School Denver | Colorado | 63.1 | |
| 91 | Pittsford-Mendon High School Pittsford | New York | 63.1 | |
| 91 | Scarsdale Senior High School Scarsdale | New York | 63.1 | |
| 94 | Animo Leadership High Inglewood | California | 62.9 | |
| 95 | Ottawa Hills High School Toledo | Ohio | 62.8 | |
| 96 | Corbett High School Corbett | Oregon | 62.5 | |
| 97 | Coeur d'Alene Charter Academy Coeur d'Alene | Idaho | 62.2 | |
| 98 | Chagrin Falls High School Chagrin Falls | Ohio | 61.4 | |
| 98 | La Jolla Senior High La Jolla | California | 61.4 | |
| 100 | Belmont High Belmont | Massachusetts | 61.2 | |