During the history of the United States, eight presidents have died in office. Of those eight, four were assassinated, and four died of natural causes. In all eight cases, the Vice President of the United States took over the office of presidency as part of the United States presidential line of succession. William Henry Harrison holds the record for shortest term served, holding the office of presidency for 31 days before passing away, as well as being the first president to die in office. Franklin Delano Roosevelt held the office of presidency longer than any other president, including those who completed their terms, with a total of four terms or 4,422 days.