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St. Louis /seɪnt ˈluːɪs/ is an independent city on the eastern border of Missouri, United States, and is the second-largest city in the state. With a population of 319,294, it was the 58th-largest U.S. city at the 2010 U.S. Census. The Metropolitan Statistical Area population... of 2,812,896 is the 18th-largest in the country. The Greater St. Louis combined statistical area's population of 2,878,255 is the 16th-largest CSA in the country, the fourth-largest in the Midwest. The Greater St. Louis area is the largest metropolitan area in Missouri. The city of St. Louis was founded in 1764 by Pierre Laclède and Auguste Chouteau, and after the Louisiana Purchase, it became a major port on the Mississippi River. Its population expanded after the American Civil War, and it became the fourth-largest city in the United States in the late 19th century. It seceded from St. Louis County in March 1877, allowing it to become an independent city and limiting its political boundaries. In 1904, it hosted the 1904 World's Fair and the 1904 Olympic Games.
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